Designer Opioids


Novel synthetic opioids have recently emerged on the NPS recreational drug market. Opioid use is motivated by habit, addiction, and as a coping mechanism, in addition to the pleasure appeal. Designer opioids include derivatives of the therapeutic drug, fentanyl, and structurally new synthetic opioids. Their effects on humans mimic the opioid toxidrome. They pose an especially serious concern for public health as they are typically more potent than traditional opioids and have high abuse liability, dependence potential, and toxicity. These opioids contribute to the growing number of acute intoxication cases, often associated with multidrug abuse. Conventional drug tests will not detect synthetic opioids.

Vanguard Lab Sciences provides definitive workplace drug testing with NIDA5 and Expanded NIDA 5 Panels that include the classic prescription and illicit opioids, alongside a comprehensive NPS Panel that includes designer opioids. The opioid test menu of 31 drugs (including 24 designer opioids) and 10 associate metabolites, is up to date, covering the most trending designer opioids.



  • Can be detected up to three days in urine


  • Relaxation
  • Pain Relief
  • Dizziness
  • Drowsiness
  • Euphoria

Common Designer:

  • U4 (U-47700)
  • Gray Death (Carfentanil)
  • Krokodil (Desomorphine)